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[128] In contrast, other DAT inhibitors like bupropion have not been noticed to exhibit this outcome.[129] These observations have prompted the speculation that methylphenidate may well work as a "DAT inverse agonist" or "destructive allosteric modifier from the DAT" by reversing the direction of your dopamine efflux by the DAT at higher dosages.[a

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Modafinil’s consequences on glutamate seem like quite diversified by Mind region. It was proven that modafinil elevated extracellular glutamate from the medial preoptic and posterior hypothalamus and this impact was a result of the reduction in GABAergic tone stated previously (Ferraro et al 1996, 1999). From the thalamus and hippocampus modafini

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